› 5c89

X-ray diffraction
1.65Å resolution

Crystal structure of the human BRPF1 bromodomain in complex with 917

Released:
DOI: 10.2210/pdb5c89/pdb
PDB entry 5c89 coloured by chain, front view.
PDB entry 5c89 coloured by chain, side view.
PDB entry 5c89 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhu J, Wiedmer L, Caflisch A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157220 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peregrin Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55201 (Residues: 627-740; Coverage: 9%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 4YT 1 x 4YT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3221
Unit cell:
a: 60.755Å b: 60.755Å c: 63.494Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.182 0.2
Expression system: Escherichia coli

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