Function and Biology Details
Reaction catalysed:
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
E3 ubiquitin-protein ligase parkin and Ubiquitin (preferred)
PDBe Complex ID:
PDB-CPX-122708 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
E3 ubiquitin-protein ligase parkin
Molecule details ›
Chains: A, C
Length: 321 amino acids
Theoretical weight: 36.1 KDa
Source organism: Pediculus humanus corporis
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 321 amino acids
Theoretical weight: 36.1 KDa
Source organism: Pediculus humanus corporis
Expression system: Escherichia coli
UniProt:
- Canonical:
E0VIU9 (Residues: 141-461; Coverage: 70%)
Sequence domains:
Ubiquitin
Molecule details ›
Chains: B, D
Length: 76 amino acids
Theoretical weight: 8.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 76 amino acids
Theoretical weight: 8.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P0CG47 (Residues: 153-228; Coverage: 33%)
Sequence domains: Ubiquitin family
