› 5cbx

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-118465 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Glucocorticoid receptor Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 105 amino acids
Theoretical weight: 11.74 KDa
Source organism: unidentified
Expression system: Escherichia coli
UniProt:
  • Canonical: P04150 (Residues: 412-495; Coverage: 11%)
Gene names: GRL, NR3C1
Sequence domains: Zinc finger, C4 type (two domains)
Structure domains: Erythroid Transcription Factor GATA-1, subunit A
DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3') Chains: C, H
Molecule details ›
Chains: C, H
Length: 18 nucleotides
Theoretical weight: 5.54 KDa
Source organism: synthetic construct
Expression system: synthetic construct
DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3') Chains: D, G
Molecule details ›
Chains: D, G
Length: 18 nucleotides
Theoretical weight: 5.47 KDa
Source organism: synthetic construct
Expression system: synthetic construct

Ligands and Environments

1 bound ligand:
Ligand ZN 8 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 47.82Å b: 81.575Å c: 116.52Å
α: 90° β: 97.19° γ: 90°
R-values:
R R work R free
0.211 0.21 0.229
Expression systems:
  • Escherichia coli
  • synthetic construct

Quick links

Citations

5 review citations

Glucocorticoid receptor control of transcription: precision and plasticity via allostery.
Weikum et al. (2017)
4 more

5 mentions without citation

Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways.
Sevilla et al. (2021)
4 more