› 5cj8

X-ray diffraction
2.02Å resolution

Human Osteoclast Associated Receptor (OSCAR) extracellular domain

Released:
DOI: 10.2210/pdb5cj8/pdb
PDB entry 5cj8 coloured by chain, front view.
PDB entry 5cj8 coloured by chain, side view.
PDB entry 5cj8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors.
Haywood J, Qi J, Chen CC, Lu G, Liu Y, Yan J, Shi Y, Gao GF
Proc Natl Acad Sci U S A 113 1038-43 (2016)
PMID: 26744311

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Osteoclast-associated immunoglobulin-like receptor Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 20.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IYS5 (Residues: 31-215; Coverage: 70%)
Gene name: OSCAR
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 27.215Å b: 46.464Å c: 66.98Å
α: 90° β: 93.25° γ: 90°
R-values:
R R work R free
0.225 0.223 0.255
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The Natural Cytotoxicity Receptors in Health and Disease.
Barrow et al. (2019)
8 more

1 mention without citation

Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors.
Haywood et al. (2016)