› 5cjb

X-ray diffraction
2.4Å resolution

Human Osteoclast Associated Receptor (OSCAR) in complex with a collagen-like peptide

Released:
DOI: 10.2210/pdb5cjb/pdb
PDB entry 5cjb coloured by chain, front view.
PDB entry 5cjb coloured by chain, side view.
PDB entry 5cjb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors.
Haywood J, Qi J, Chen CC, Lu G, Liu Y, Yan J, Shi Y, Gao GF
Proc Natl Acad Sci U S A 113 1038-43 (2016)
PMID: 26744311

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165494 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Osteoclast-associated immunoglobulin-like receptor Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 20.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IYS5 (Residues: 31-215; Coverage: 70%)
Gene name: OSCAR
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins
collagen-like peptide Chains: B, C, D
Molecule details ›
Chains: B, C, D
Length: 25 amino acids
Theoretical weight: 2.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 21 x HYP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 45.94Å b: 48.424Å c: 118.055Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.264
Expression system: Escherichia coli

Quick links

Citations

8 review citations

The Natural Cytotoxicity Receptors in Health and Disease.
Barrow et al. (2019)
7 more

2 mentions without citation

Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease.
Nedeva et al. (2021)
1 more