› 5ckg

X-ray diffraction
1.75Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158314 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 100 amino acids
Theoretical weight: 11.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand ACT 2 x ACT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 88.578Å b: 28.86Å c: 87.719Å
α: 90° β: 110.11° γ: 90°
R-values:
R R work R free
0.188 0.183 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Third generation antibody discovery methods: in silico rational design.
Sormanni et al. (2018)
3 more

1 mention without citation

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
Camilloni et al. (2016)