› 5cly

X-ray diffraction
1.23Å resolution

X-ray structure of TTR mutant - S52P at 1.23A resolution

Released:
DOI: 10.2210/pdb5cly/pdb
PDB entry 5cly coloured by chain, front view.
PDB entry 5cly coloured by chain, side view.
PDB entry 5cly coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yee AW, Moulin M, Mossou E, Haertlein M, Mitchell EP, Cooper JB, Forsyth VT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 130 amino acids
Theoretical weight: 14.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 43.017Å b: 85.929Å c: 63.964Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.157 0.186
Expression system: Escherichia coli

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