› 5cm4

X-ray diffraction
2.4Å resolution

Crystal structure of human Frizzled 4 Cysteine-Rich Domain (CRD)

Released:
DOI: 10.2210/pdb5cm4/pdb
PDB entry 5cm4 coloured by chain, front view.
PDB entry 5cm4 coloured by chain, side view.
PDB entry 5cm4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the Norrin-Frizzled 4 interaction.
Shen G, Ke J, Wang Z, Cheng Z, Gu X, Wei Y, Melcher K, Xu HE, Xu W
Cell Res 25 1078-81 (2015)
PMID: 26227961

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193934 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Frizzled-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9ULV1 (Residues: 40-164; Coverage: 25%)
Gene name: FZD4
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: C2221
Unit cell:
a: 105.583Å b: 111.738Å c: 75.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.226 0.255
Expression system: Homo sapiens

Quick links

Citations

6 review citations

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
5 more

6 mentions without citation

Assembly and architecture of the Wnt/β-catenin signalosome at the membrane.
DeBruine et al. (2017)
5 more