› 5cmr

X-ray diffraction
3.79Å resolution

Crystal Structure of Linker-Mediated Zn-bound Human H-Ferritin variant 122H-delta C-star

Released:
DOI: 10.2210/pdb5cmr/pdb
PDB entry 5cmr coloured by chain, front view.
PDB entry 5cmr coloured by chain, side view.
PDB entry 5cmr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals.
Sontz PA, Bailey JB, Ahn S, Tezcan FA
J Am Chem Soc 137 11598-601 (2015)
PMID: 26305584

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand NA 3 x NA
Ligand BYD 1 x BYD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: I432
Unit cell:
a: 155.32Å b: 155.32Å c: 155.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.207 0.256
Expression system: Escherichia coli

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Citations

15 review citations

Nanoscale Metal-Organic Frameworks for Therapeutic, Imaging, and Sensing Applications.
Lu et al. (2018)
14 more