› 5cmz

X-ray diffraction
2.57Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137980 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chains: A, C
Molecule details ›
Chains: A, C
Length: 46 amino acids
Theoretical weight: 5.23 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 546-590; Coverage: 6%)
Gene name: env
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Artificial HIV entry inhibitor AP3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 38 amino acids
Theoretical weight: 4.68 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand EDO 1 x EDO
Ligand P4G 1 x P4G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P63
Unit cell:
a: 44.403Å b: 44.403Å c: 227.897Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.245 0.264
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

9 review citations

The current understanding and potential therapeutic options to combat COVID-19.
Pooladanda et al. (2020)
8 more

2 mentions without citation

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy.
Zhu et al. (2015)
1 more