› 5cnm

X-ray diffraction
2.84Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172107 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 517 amino acids
Theoretical weight: 58.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14832 (Residues: 2-507; Coverage: 57%)
Gene names: GPRC1C, GRM3, MGLUR3
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

4 bound ligands:
Ligand 52Q 1 x 52Q
Ligand CL 2 x CL
Ligand SO4 1 x SO4
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 84.892Å b: 99.025Å c: 71.172Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.226
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Molecular insights into allosteric modulation of Class C G protein-coupled receptors.
Leach et al. (2017)
1 more

2 mentions without citation

Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Wang et al. (2023)
1 more