› 5cr1

X-ray diffraction
1.54Å resolution

Crystal structure of TTR/resveratrol/T4 complex

Released:
DOI: 10.2210/pdb5cr1/pdb
PDB entry 5cr1 coloured by chain, front view.
PDB entry 5cr1 coloured by chain, side view.
PDB entry 5cr1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites.
Florio P, Folli C, Cianci M, Del Rio D, Zanotti G, Berni R
J Biol Chem 290 29769-80 (2015)
PMID: 26468275

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 12.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 30-145; Coverage: 91%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

2 bound ligands:
Ligand T44 1 x T44
Ligand STL 1 x STL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21212
Unit cell:
a: 42.536Å b: 85.633Å c: 63.826Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.193
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?
Weiskirchen et al. (2016)
8 more

7 mentions without citation

Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets.
Saqib et al. (2018)
6 more