› 5cum

X-ray diffraction
1.75Å resolution

Crystal structure of Human Defensin-5 Y27A mutant crystal form 1.

Released:
DOI: 10.2210/pdb5cum/pdb
PDB entry 5cum coloured by chain, front view.
PDB entry 5cum coloured by chain, side view.
PDB entry 5cum coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.
Xu D, Liao C, Zhang B, Tolbert WD, He W, Dai Z, Zhang W, Yuan W, Pazgier M, Liu J, Yu J, Sansonetti PJ, Bevins CL, Shao Y, Lu W
Immunity 48 1233-1244.e6 (2018)
PMID: 29858013

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HD5(63-94) Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 32 amino acids
Theoretical weight: 3.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q01523 (Residues: 63-94; Coverage: 43%)
Gene names: DEF5, DEFA5
Sequence domains: Mammalian defensin

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand CL 6 x CL
Ligand IPA 3 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 47.603Å b: 59.966Å c: 38.272Å
α: 90° β: 111.36° γ: 90°
R-values:
R R work R free
0.175 0.173 0.22
Expression system: Not provided

Quick links

Citations

9 review citations

Antimicrobial peptides: mechanism of action, activity and clinical potential.
Zhang et al. (2021)
8 more