› 5cvl

X-ray diffraction
3Å resolution

WDR48 (UAF-1), residues 2-580

Released:
DOI: 10.2210/pdb5cvl/pdb
PDB entry 5cvl coloured by chain, front view.
PDB entry 5cvl coloured by chain, side view.
PDB entry 5cvl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Yin J, Schoeffler AJ, Wickliffe K, Newton K, Starovasnik MA, Dueber EC, Harris SF
Structure 23 2043-54 (2015)
PMID: 26388029

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 48 Chain: A
Molecule details ›
Chain: A
Length: 598 amino acids
Theoretical weight: 67.15 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8TAF3 (Residues: 2-580; Coverage: 86%)
Gene names: KIAA1449, UAF1, WDR48
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PO4 2 x PO4
Ligand AU 7 x AU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: I4122
Unit cell:
a: 139.52Å b: 139.52Å c: 235.109Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.186 0.233
Expression system: Trichoplusia ni

Quick links

Citations

6 review citations

Mechanisms of Deubiquitinase Specificity and Regulation.
Mevissen et al. (2017)
5 more

1 mention without citation

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
Dharadhar et al. (2016)