› 5d4k

X-ray diffraction
2.6Å resolution

Crystal structure of the human polymeric Ig receptor (pIgR) ectodomain

Released:
DOI: 10.2210/pdb5d4k/pdb
PDB entry 5d4k coloured by chain, front view.
PDB entry 5d4k coloured by chain, side view.
PDB entry 5d4k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins.
Stadtmueller BM, Huey-Tubman KE, López CJ, Yang Z, Hubbell WL, Bjorkman PJ
Elife 5 (2016)
PMID: 26943617

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134608 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Secretory component Chains: A, B
Molecule details ›
Chains: A, B
Length: 557 amino acids
Theoretical weight: 61.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01833 (Residues: 19-565; Coverage: 73%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 6 x NAG
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 61.258Å b: 242.434Å c: 63.046Å
α: 90° β: 114.89° γ: 90°
R-values:
R R work R free
0.203 0.201 0.254
Expression system: Homo sapiens

Quick links

Citations

17 review citations

IgA and the intestinal microbiota: the importance of being specific.
Pabst et al. (2020)
16 more

12 mentions without citation

IgA: Structure, Function, and Developability.
de Sousa-Pereira et al. (2019)
11 more