Function and Biology Details
Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156537 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1
Molecule details ›
Chain: C
Length: 466 amino acids
Theoretical weight: 50.46 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Length: 466 amino acids
Theoretical weight: 50.46 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
P52293 (Residues: 70-529; Coverage: 87%)
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Poly [ADP-ribose] polymerase 2
Molecule details ›
Chain: B
Length: 98 amino acids
Theoretical weight: 10.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Length: 98 amino acids
Theoretical weight: 10.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9UGN5 (Residues: 1-91; Coverage: 13%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X29A
Spacegroup:
P212121
Expression system: Escherichia coli
