› 5da3

X-ray diffraction
1.7Å resolution

Crystal structure of PTK6 Kinase domain with inhibitor

Released:
DOI: 10.2210/pdb5da3/pdb
PDB entry 5da3 coloured by chain, front view.
PDB entry 5da3 coloured by chain, side view.
PDB entry 5da3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution.
Thakur MK, Birudukota S, Swaminathan S, Battula SK, Vadivelu S, Tyagi R, Gosu R
Biochem Biophys Res Commun 482 1289-1295 (2017)
PMID: 27993680

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-tyrosine kinase 6 Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 30.59 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13882 (Residues: 185-446; Coverage: 58%)
Gene names: BRK, PTK6
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand 58V 1 x 58V
1 modified residue:
Ligand CXM 1 x CXM

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 90.372Å b: 48.403Å c: 71.924Å
α: 90° β: 105.14° γ: 90°
R-values:
R R work R free
0.199 0.197 0.23
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Putting the BRK on breast cancer: From molecular target to therapeutics.
Ang et al. (2021)
2 more

2 mentions without citation

Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution.
Thakur et al. (2017)
1 more