› 5dbr

X-ray diffraction
2.25Å resolution

Ca2+ CaM with human cardiac Na+ channel (NaV1.5) inactivation gate

Released:
DOI: 10.2210/pdb5dbr/pdb
PDB entry 5dbr coloured by chain, front view.
PDB entry 5dbr coloured by chain, side view.
PDB entry 5dbr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Johnson CN, Thompson MK, Chazin WJ

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143949 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-1 Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DP23 (Residues: 5-149; Coverage: 97%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair
Sodium channel protein type 5 subunit alpha Chain: C
Molecule details ›
Chain: C
Length: 51 amino acids
Theoretical weight: 5.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14524 (Residues: 1483-1529; Coverage: 2%)
Gene name: SCN5A

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P3221
Unit cell:
a: 58.086Å b: 58.086Å c: 102.638Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.22 0.284
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli

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