› 5dcn

X-ray diffraction
2Å resolution

Crystal structure of LC3 in complex with TECPR2 LIR

Released:
DOI: 10.2210/pdb5dcn/pdb
PDB entry 5dcn coloured by chain, front view.
PDB entry 5dcn coloured by chain, side view.
PDB entry 5dcn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.
Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel BC, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C
Mol Cell 60 89-104 (2015)
PMID: 26431026

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated proteins 1A/1B light chain 3B Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZQ8 (Residues: 2-119; Coverage: 94%)
Gene names: MAP1ALC3, MAP1LC3B
Sequence domains: Autophagy protein Atg8 ubiquitin like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3221
Unit cell:
a: 60.705Å b: 60.705Å c: 99.946Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.209 0.247
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
Menzies et al. (2017)
34 more