› 5dhh

X-ray diffraction
3Å resolution

The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target)

Released:
DOI: 10.2210/pdb5dhh/pdb
PDB entry 5dhh coloured by chain, front view.
PDB entry 5dhh coloured by chain, side view.
PDB entry 5dhh coloured by chain, top view.
Source organisms:
Primary publication:
The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor.
Miller RL, Thompson AA, Trapella C, Guerrini R, Malfacini D, Patel N, Han GW, Cherezov V, Caló G, Katritch V, Stevens RC
Structure 23 2291-2299 (2015)
PMID: 26526853

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-142085 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nociceptin receptor; Soluble cytochrome b562 Chains: A, B
Molecule details ›
Chains: A, B
Length: 424 amino acids
Theoretical weight: 46.7 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: P41146 (Residues: 43-339; Coverage: 80%)
Gene names: OOR, OPRL1, ORL1, cybC
Sequence domains:
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

3 bound ligands:
Ligand OLA 7 x OLA
Ligand DGW 2 x DGW
Ligand OLC 1 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 42.3Å b: 168.941Å c: 65.472Å
α: 90° β: 103.5° γ: 90°
R-values:
R R work R free
0.242 0.24 0.279
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

Structure and Function of Peptide-Binding G Protein-Coupled Receptors.
Wu et al. (2017)
8 more

14 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
13 more