› 5dkh

X-ray diffraction
1.7Å resolution

Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17

Released:
DOI: 10.2210/pdb5dkh/pdb
PDB entry 5dkh coloured by chain, front view.
PDB entry 5dkh coloured by chain, side view.
PDB entry 5dkh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Owen DR, Taylor A, Fedorov O, Savitsky P, Siejka P, Srikannathasan V, Nowak R, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable global transcription activator SNF2L2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 123 amino acids
Theoretical weight: 14.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51531 (Residues: 1373-1511; Coverage: 8%)
Gene names: BAF190B, BRM, SMARCA2, SNF2A, SNF2L2
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

3 bound ligands:
Ligand ZN 6 x ZN
Ligand 5C0 2 x 5C0
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P31
Unit cell:
a: 63.997Å b: 63.997Å c: 89.16Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.241
Expression system: Escherichia coli

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