5dmj

X-ray diffraction
2.79Å resolution

Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-229927 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor receptor superfamily member 5 Chains: A, D, F
Molecule details ›
Chains: A, D, F
Length: 183 amino acids
Theoretical weight: 20.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P25942 (Residues: 23-193; Coverage: 67%)
Gene names: CD40, TNFRSF5
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2
3H65-5 domain antibody (dAb) Chains: B, E, G
Molecule details ›
Chains: B, E, G
Length: 121 amino acids
Theoretical weight: 13.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 199.3Å b: 48.7Å c: 138.8Å
α: 90° β: 118.2° γ: 90°
R-values:
R R work R free
0.23 0.229 0.258
Expression systems:
  • Homo sapiens
  • Escherichia coli