› 5du3

X-ray diffraction
2.1Å resolution

Active form of human C1-inhibitor

Released:
DOI: 10.2210/pdb5du3/pdb
PDB entry 5du3 coloured by chain, front view.
PDB entry 5du3 coloured by chain, side view.
PDB entry 5du3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation.
Dijk M, Holkers J, Voskamp P, Giannetti BM, Waterreus WJ, van Veen HA, Pannu NS
Structure 24 2182-2189 (2016)
PMID: 27818099

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138561 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasma protease C1 inhibitor Chains: A, B
Molecule details ›
Chains: A, B
Length: 382 amino acids
Theoretical weight: 42.78 KDa
Source organism: Homo sapiens
Expression system: Oryctolagus cuniculus
UniProt:
  • Canonical: P05155 (Residues: 119-500; Coverage: 80%)
Gene names: C1IN, C1NH, SERPING1
Sequence domains: Serpin (serine protease inhibitor)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 57.41Å b: 75.38Å c: 203.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.257
Expression system: Oryctolagus cuniculus

Quick links

Citations

2 review citations

A bite so sweet: the glycobiology interface of tick-host-pathogen interactions.
Vechtova et al. (2018)
1 more

8 mentions without citation

SERPING1 Variants and C1-INH Biological Function: A Close Relationship With C1-INH-HAE.
Drouet et al. (2022)
7 more