› 5duq

X-ray diffraction
2.9Å resolution

Active human c1-inhibitor in complex with dextran sulfate

Released:
DOI: 10.2210/pdb5duq/pdb
PDB entry 5duq coloured by chain, front view.
PDB entry 5duq coloured by chain, side view.
PDB entry 5duq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation.
Dijk M, Holkers J, Voskamp P, Giannetti BM, Waterreus WJ, van Veen HA, Pannu NS
Structure 24 2182-2189 (2016)
PMID: 27818099

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Plasma protease C1 inhibitor Chains: A, B
Molecule details ›
Chains: A, B
Length: 383 amino acids
Theoretical weight: 42.91 KDa
Source organism: Homo sapiens
Expression system: Oryctolagus cuniculus
UniProt:
  • Canonical: P05155 (Residues: 118-500; Coverage: 80%)
Gene names: C1IN, C1NH, SERPING1
Sequence domains: Serpin (serine protease inhibitor)

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC, BGC
Carbohydrate polymer
3 bound ligands:
Ligand NAG 2 x NAG
Ligand GLC 1 x GLC
Ligand SO3 1 x SO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 112.1Å b: 197.424Å c: 56.779Å
α: 90° β: 103.31° γ: 90°
R-values:
R R work R free
0.231 0.228 0.278
Expression system: Oryctolagus cuniculus

Quick links

Citations

2 review citations

A bite so sweet: the glycobiology interface of tick-host-pathogen interactions.
Vechtova et al. (2018)
1 more