› 5dv8

X-ray diffraction
2.75Å resolution

Human PPARgamma ligand binding dmain complexed with SB1451 in a covalent bonded form

Released:
DOI: 10.2210/pdb5dv8/pdb
PDB entry 5dv8 coloured by chain, front view.
PDB entry 5dv8 coloured by chain, side view.
PDB entry 5dv8 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Jang JY

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153375 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 223-505; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 685-700; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

1 bound ligand:
Ligand T51 1 x T51
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P21212
Unit cell:
a: 55.27Å b: 131.296Å c: 51.968Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.243
Expression systems:
  • Escherichia coli
  • Not provided

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