› 5dzz

X-ray diffraction
2.6Å resolution

Structural characterization of intermediate filaments binding domain of desmoplakin

Released:
DOI: 10.2210/pdb5dzz/pdb
PDB entry 5dzz coloured by chain, front view.
PDB entry 5dzz coloured by chain, side view.
PDB entry 5dzz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Intermediate Filament-Binding Region of Desmoplakin.
Kang H, Weiss TM, Bang I, Weis WI, Choi HJ
PLoS One 11 e0147641 (2016)
PMID: 26808545

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Desmoplakin Chain: A
Molecule details ›
Chain: A
Length: 494 amino acids
Theoretical weight: 54.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15924 (Residues: 1960-2448; Coverage: 17%)
Gene name: DSP
Sequence domains: Plectin repeat
Structure domains: Plakin repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 111.931Å b: 64.466Å c: 74.044Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.207 0.264
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics.
Hatzfeld et al. (2017)
6 more

1 mention without citation

Missense Mutations in Desmoplakin Plakin Repeat Domains Have Dramatic Effects on Domain Structure and Function.
Mohammed et al. (2022)