› 5e6s

X-ray diffraction
2.15Å resolution

Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand

Released:
DOI: 10.2210/pdb5e6s/pdb
PDB entry 5e6s coloured by chain, front view.
PDB entry 5e6s coloured by chain, side view.
PDB entry 5e6s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
Sen M, Springer TA
Proc Natl Acad Sci U S A 113 2940-5 (2016)
PMID: 26936951

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-138497 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin alpha-L Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 795 amino acids
Theoretical weight: 87.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20701 (Residues: 26-770; Coverage: 65%)
Gene names: CD11A, ITGAL
Sequence domains:
Structure domains:
Integrin beta-2 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 510 amino acids
Theoretical weight: 56.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-482; Coverage: 62%)
Gene names: CD18, ITGB2, MFI7
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 3 x MG
Ligand CA 15 x CA
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 151.9Å b: 118.877Å c: 150.967Å
α: 90° β: 118.52° γ: 90°
R-values:
R R work R free
0.196 0.194 0.234
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Research advances on structure and biological functions of integrins.
Pan et al. (2016)
4 more

5 mentions without citation

Structural Immunology of Complement Receptors 3 and 4.
Vorup-Jensen et al. (2018)
4 more