› 5e6u

X-ray diffraction
2.5Å resolution

Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand

Released:
DOI: 10.2210/pdb5e6u/pdb
PDB entry 5e6u coloured by chain, front view.
PDB entry 5e6u coloured by chain, side view.
PDB entry 5e6u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
Sen M, Springer TA
Proc Natl Acad Sci U S A 113 2940-5 (2016)
PMID: 26936951

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138497 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin alpha-L Chain: A
Molecule details ›
Chain: A
Length: 795 amino acids
Theoretical weight: 87.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20701 (Residues: 26-770; Coverage: 65%)
Gene names: CD11A, ITGAL
Sequence domains:
Structure domains:
Integrin beta-2 Chain: B
Molecule details ›
Chain: B
Length: 510 amino acids
Theoretical weight: 56.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-482; Coverage: 62%)
Gene names: CD18, ITGB2, MFI7
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand MG 2 x MG
Ligand CA 4 x CA
Ligand CL 1 x CL
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P61
Unit cell:
a: 154.98Å b: 154.98Å c: 115.45Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.179 0.226
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Research advances on structure and biological functions of integrins.
Pan et al. (2016)
5 more

6 mentions without citation

Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
Sen et al. (2016)
5 more