› 5e6v

X-ray diffraction
1.8Å resolution

Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit

Released:
DOI: 10.2210/pdb5e6v/pdb
PDB entry 5e6v coloured by chain, front view.
PDB entry 5e6v coloured by chain, side view.
PDB entry 5e6v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
Sen M, Springer TA
Proc Natl Acad Sci U S A 113 2940-5 (2016)
PMID: 26936951

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Integrin beta-2 Chain: A
Molecule details ›
Chain: A
Length: 224 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-482; Coverage: 30%)
Gene names: CD18, ITGB2, MFI7
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUL
Carbohydrate polymer
No bound ligands
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 58.6Å b: 31.818Å c: 74.95Å
α: 90° β: 91.2° γ: 90°
R-values:
R R work R free
0.18 0.177 0.229
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Research advances on structure and biological functions of integrins.
Pan et al. (2016)
4 more

2 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
1 more