› 5e6w

X-ray diffraction
2.2Å resolution

Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit

Released:
DOI: 10.2210/pdb5e6w/pdb
PDB entry 5e6w coloured by chain, front view.
PDB entry 5e6w coloured by chain, side view.
PDB entry 5e6w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
Sen M, Springer TA
Proc Natl Acad Sci U S A 113 2940-5 (2016)
PMID: 26936951

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-2 Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 34.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-118, 362-574; Coverage: 41%)
Gene names: CD18, ITGB2, MFI7
Sequence domains: Integrin plexin domain

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6522
Unit cell:
a: 52.26Å b: 52.26Å c: 423.924Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.227 0.27
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Structural Immunology of Complement Receptors 3 and 4.
Vorup-Jensen et al. (2018)
4 more

2 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
1 more