› 5e6x

X-ray diffraction
1.75Å resolution

Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit

Released:
DOI: 10.2210/pdb5e6x/pdb
PDB entry 5e6x coloured by chain, front view.
PDB entry 5e6x coloured by chain, side view.
PDB entry 5e6x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
Sen M, Springer TA
Proc Natl Acad Sci U S A 113 2940-5 (2016)
PMID: 26936951

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-2 Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 31.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-535; Coverage: 37%)
Gene names: CD18, ITGB2, MFI7
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 58.489Å b: 30.853Å c: 65.157Å
α: 90° β: 94.29° γ: 90°
R-values:
R R work R free
0.199 0.197 0.245
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Structural Immunology of Complement Receptors 3 and 4.
Vorup-Jensen et al. (2018)
4 more

2 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
1 more