Function and Biology Details
Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128839 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
mRNA cap guanine-N7 methyltransferase
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 36.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: mRNA (guanine-N(7))-methyltransferase domain
Structure domains: Vaccinia Virus protein VP39
Length: 312 amino acids
Theoretical weight: 36.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O43148 (Residues: 165-476; Coverage: 66%)
Sequence domains: mRNA (guanine-N(7))-methyltransferase domain
Structure domains: Vaccinia Virus protein VP39
RNA guanine-N7 methyltransferase activating subunit
Molecule details ›
Chains: C, D
Length: 44 amino acids
Theoretical weight: 5.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: mRNA cap methylation, RNMT-activating mini protein
Length: 44 amino acids
Theoretical weight: 5.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9BTL3 (Residues: 2-45; Coverage: 37%)
Sequence domains: mRNA cap methylation, RNMT-activating mini protein
