› 5eal

X-ray diffraction
1.8Å resolution

Crystal structure of human WDR5 in complex with compound 9h

Released:
DOI: 10.2210/pdb5eal/pdb
PDB entry 5eal coloured by chain, front view.
PDB entry 5eal coloured by chain, side view.
PDB entry 5eal coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: DONG A, DOMBROVSKI L, SMIL D, GETLIK M, BOLSHAN Y, WALKER JR, SENISTERRA G, PODA G, AL-AWAR R, SCHAPIRA M, VEDADI M, Bountra C, Edwards AM, Arrowsmith CH, BROWN PJ, WU H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158474 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

5 bound ligands:
Ligand 5ML 2 x 5ML
Ligand GOL 1 x GOL
Ligand CL 1 x CL
Ligand EDO 17 x EDO
Ligand UNX 24 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P1
Unit cell:
a: 47.191Å b: 60.962Å c: 64.126Å
α: 110.67° β: 90.43° γ: 109.47°
R-values:
R R work R free
0.179 0.178 0.211
Expression system: Escherichia coli BL21(DE3)

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