› 5eel

X-ray diffraction
2.47Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165594 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 7 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 120 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14451 (Residues: 415-532; Coverage: 22%)
Gene name: GRB7
Sequence domains: SH2 domain
Structure domains: SH2 domain
Bicyclic Peptide Inhibitor Chains: L, M, N, P, Q, R
Molecule details ›
Chains: L, M, N, P, Q, R
Length: 9 amino acids
Theoretical weight: 1.13 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand MLA 5 x MLA
Ligand FMT 6 x FMT
Ligand NA 6 x NA
2 modified residues:
Ligand 73C 6 x 73C
Ligand AEA 6 x AEA

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P41212
Unit cell:
a: 95.228Å b: 95.228Å c: 241.566Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.185 0.232
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

Arylation Chemistry for Bioconjugation.
Zhang et al. (2019)
3 more

5 mentions without citation

Miniproteins as a Powerful Modality in Drug Development.
Crook et al. (2020)
4 more