› 5efm

X-ray diffraction
1.95Å resolution

Beclin 1 Flexible-helical Domian (FHD) (141-171)

Released:
DOI: 10.2210/pdb5efm/pdb
PDB entry 5efm coloured by chain, front view.
PDB entry 5efm coloured by chain, side view.
PDB entry 5efm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational Flexibility Enables the Function of a BECN1 Region Essential for Starvation-Mediated Autophagy.
Mei Y, Ramanathan A, Glover K, Stanley C, Sanishvili R, Chakravarthy S, Yang Z, Colbert CL, Sinha SC
Biochemistry 55 1945-58 (2016)
PMID: 26937551

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beclin-1-C 35 kDa Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q14457 (Residues: 141-171; Coverage: 7%)
Gene names: BECN1, GT197

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P4332
Unit cell:
a: 63.163Å b: 63.163Å c: 63.163Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.212 0.216
Expression system: Not provided

Quick links

Citations

6 review citations

Conformational flexibility of BECN1: Essential to its key role in autophagy and beyond.
Mei et al. (2016)
5 more

2 mentions without citation

Conformational Flexibility Enables the Function of a BECN1 Region Essential for Starvation-Mediated Autophagy.
Mei et al. (2016)
1 more