› 5efs

X-ray diffraction
1.83Å resolution

The crystal structure of human kynurenine aminotransferase II

Released:
DOI: 10.2210/pdb5efs/pdb
PDB entry 5efs coloured by chain, front view.
PDB entry 5efs coloured by chain, side view.
PDB entry 5efs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nematollahi A, Sun G, Kwan A, Harrop SJ, Hanrahan JR, Nadvi NA, Church WB

Function and Biology Details

Reactions catalysed: 
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
Glycine + 2-oxoglutarate = glyoxylate + L-glutamate
(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine 
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 425 amino acids
Theoretical weight: 47.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N5Z0 (Residues: 1-425; Coverage: 100%)
Gene names: AADAT, KAT2, KYAT2
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 102.455Å b: 102.455Å c: 86.236Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.169 0.192
Expression system: Escherichia coli

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