› 5eh1

X-ray diffraction
1.8Å resolution

Crystal structure of the extracellular part of receptor 2 of human interferon gamma

Released:
DOI: 10.2210/pdb5eh1/pdb
PDB entry 5eh1 coloured by chain, front view.
PDB entry 5eh1 coloured by chain, side view.
PDB entry 5eh1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human interferon-γ receptor 2 reveals the structural basis for receptor specificity.
Mikulecký P, Zahradník J, Kolenko P, Černý J, Charnavets T, Kolářová L, Nečasová I, Pham PN, Schneider B
Acta Crystallogr D Struct Biol 72 1017-25 (2016)
PMID: 27599734

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153655 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon gamma receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 26.21 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P38484 (Residues: 28-247; Coverage: 70%)
Gene names: IFNGR2, IFNGT1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand CYS 1 x CYS
Ligand NAG 3 x NAG
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P6122
Unit cell:
a: 58.102Å b: 58.102Å c: 377.266Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.19 0.222
Expression system: Drosophila melanogaster

Quick links

Citations

1 review citation

Review of the recombinant human interferon gamma as an immunotherapeutic: Impacts of production platforms and glycosylation.
Razaghi et al. (2016)
2 other articles

3 mentions without citation

Crystal structure of human interferon-γ receptor 2 reveals the structural basis for receptor specificity.
Mikulecký et al. (2016)
2 more