› 5ehr

X-ray diffraction
1.7Å resolution

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 526 amino acids
Theoretical weight: 60.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 1-525; Coverage: 89%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 5OD 2 x 5OD
Ligand PO4 6 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 46.19Å b: 213.79Å c: 55.89Å
α: 90° β: 96.88° γ: 90°
R-values:
R R work R free
0.196 0.195 0.221
Expression system: Escherichia coli

Quick links

Citations

99 review citations

RAS-targeted therapies: is the undruggable drugged?
Moore et al. (2020)
98 more

25 mentions without citation

Turn and Face the Strange: A New View on Phosphatases.
Köhn M. (2020)
24 more