› 5elr

X-ray diffraction
2.3Å resolution

Structure of the KH-QUA2 domain of T-STAR in complex with AAUAAU RNA

Released:
DOI: 10.2210/pdb5elr/pdb
PDB entry 5elr coloured by chain, front view.
PDB entry 5elr coloured by chain, side view.
PDB entry 5elr coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang HS, Dalgliesh C, Meyer NH, Liu Y, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C
Nat Commun 7 10355 (2016)
PMID: 26758068

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131006 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
KH domain-containing, RNA-binding, signal transduction-associated protein 3 Chains: C, D
Molecule details ›
Chains: C, D
Length: 136 amino acids
Theoretical weight: 15.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75525 (Residues: 50-183; Coverage: 39%)
Gene names: KHDRBS3, SALP, SLM2
RNA (5'-R(*AP*AP*UP*AP*AP*U)-3') Chain: B
Molecule details ›
Chain: B
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 42.38Å b: 45.56Å c: 151.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.227 0.269
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

9 review citations

RNA splicing and splicing regulator changes in prostate cancer pathology.
Munkley et al. (2017)
8 more

2 mentions without citation

Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Feracci et al. (2016)
1 more