› 5els

X-ray diffraction
2.87Å resolution

Structure of the KH domain of T-STAR in complex with AAAUAA RNA

Released:
DOI: 10.2210/pdb5els/pdb
PDB entry 5els coloured by chain, front view.
PDB entry 5els coloured by chain, side view.
PDB entry 5els coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang HS, Dalgliesh C, Meyer NH, Liu Y, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C
Nat Commun 7 10355 (2016)
PMID: 26758068

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-131007 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
KH domain-containing, RNA-binding, signal transduction-associated protein 3 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 113 amino acids
Theoretical weight: 12.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75525 (Residues: 50-160; Coverage: 32%)
Gene names: KHDRBS3, SALP, SLM2
RNA (5'-R(P*AP*AP*AP*UP*AP*A)-3') Chains: H, I
Molecule details ›
Chains: H, I
Length: 6 nucleotides
Theoretical weight: 1.91 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 93.73Å b: 162.22Å c: 113.04Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.236
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

8 review citations

RNA splicing and splicing regulator changes in prostate cancer pathology.
Munkley et al. (2017)
7 more

4 mentions without citation

RNA-Binding Proteins in Acute Leukemias.
Schuschel et al. (2020)
3 more