› 5emw

X-ray diffraction
2.55Å resolution

Crystal structure of the palmitoylated human TEAD3 transcription factor

Released:
DOI: 10.2210/pdb5emw/pdb
PDB entry 5emw coloured by chain, front view.
PDB entry 5emw coloured by chain, side view.
PDB entry 5emw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
Noland CL, Gierke S, Schnier PD, Murray J, Sandoval WN, Sagolla M, Dey A, Hannoush RN, Fairbrother WJ, Cunningham CN
Structure 24 179-186 (2016)
PMID: 26724994

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional enhancer factor TEF-5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 217 amino acids
Theoretical weight: 25.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99594 (Residues: 219-435; Coverage: 50%)
Gene names: TEAD3, TEAD5, TEF5
Sequence domains: YAP binding domain
Structure domains: Coagulation Factor XIII; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
1 modified residue:
Ligand P1L 4 x P1L

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 65.31Å b: 123.53Å c: 150.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.223
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

50 review citations

The Hippo Signaling Pathway in Development and Disease.
Zheng et al. (2019)
49 more

4 mentions without citation

Repurposing of Drugs Targeting YAP-TEAD Functions.
Elisi et al. (2018)
3 more