5epk

X-ray diffraction
1.8Å resolution

Crystal Structure of chromodomain of CBX2 in complex with inhibitor UNC3866

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-165610 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chromobox protein homolog 2 Chain: A
Molecule details ›
Chain: A
Length: 55 amino acids
Theoretical weight: 6.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14781 (Residues: 8-62; Coverage: 10%)
Gene name: CBX2
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
unc3866 Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 795 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P6
Unit cell:
a: 78.894Å b: 78.894Å c: 30.609Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.189 0.212
Expression systems:
  • Escherichia coli
  • Not provided