› 5eqx

X-ray diffraction
3.05Å resolution

Crystal structure of human Desmoglein-3 ectodomain

Released:
DOI: 10.2210/pdb5eqx/pdb
PDB entry 5eqx coloured by chain, front view.
PDB entry 5eqx coloured by chain, side view.
PDB entry 5eqx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of adhesive binding by desmocollins and desmogleins.
Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L
Proc Natl Acad Sci U S A 113 7160-5 (2016)
PMID: 27298358

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152511 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Desmoglein-3 Chain: A
Molecule details ›
Chain: A
Length: 555 amino acids
Theoretical weight: 61.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P32926 (Residues: 50-598; Coverage: 56%)
Gene names: CDHF6, DSG3
Sequence domains: Cadherin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 1 x NAG
Ligand CA 8 x CA
Ligand MAN 3 x MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P2
Unit cell:
a: 81.909Å b: 44.862Å c: 106.699Å
α: 90° β: 102.92° γ: 90°
R-values:
R R work R free
0.238 0.236 0.273
Expression system: Homo sapiens

Quick links

Citations

34 review citations

Pemphigus.
Kasperkiewicz et al. (2017)
33 more

6 mentions without citation

Structural basis of adhesive binding by desmocollins and desmogleins.
Harrison et al. (2016)
5 more