› 5er7

X-ray diffraction
3.29Å resolution

Connexin-26 Bound to Calcium

Released:
DOI: 10.2210/pdb5er7/pdb
PDB entry 5er7 coloured by chain, front view.
PDB entry 5er7 coloured by chain, side view.
PDB entry 5er7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.
Bennett BC, Purdy MD, Baker KA, Acharya C, McIntire WE, Stevens RC, Zhang Q, Harris AL, Abagyan R, Yeager M
Nat Commun 7 8770 (2016)
PMID: 26753910

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction beta-2 protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 226 amino acids
Theoretical weight: 26.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29033 (Residues: 1-226; Coverage: 100%)
Gene name: GJB2
Sequence domains: Connexin

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R32
Unit cell:
a: 156.092Å b: 156.092Å c: 160.077Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.281 0.279 0.318
Expression system: Spodoptera frugiperda

Quick links

Citations

23 review citations

Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function.
Mammano F. (2019)
22 more

10 mentions without citation

Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.
Bargiello et al. (2018)
9 more