› 5era

X-ray diffraction
3.8Å resolution

Human Connexin-26 (Calcium-free)

Released:
DOI: 10.2210/pdb5era/pdb
PDB entry 5era coloured by chain, front view.
PDB entry 5era coloured by chain, side view.
PDB entry 5era coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.
Bennett BC, Purdy MD, Baker KA, Acharya C, McIntire WE, Stevens RC, Zhang Q, Harris AL, Abagyan R, Yeager M
Nat Commun 7 8770 (2016)
PMID: 26753910

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dodecamer
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151334 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction beta-2 protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 226 amino acids
Theoretical weight: 26.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29033 (Residues: 1-226; Coverage: 100%)
Gene name: GJB2
Sequence domains: Connexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: R32
Unit cell:
a: 155.727Å b: 155.727Å c: 160.699Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.304 0.3 0.333
Expression system: Spodoptera frugiperda

Quick links

Citations

22 review citations

Therapeutic strategies targeting connexins.
Laird et al. (2018)
21 more

9 mentions without citation

Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.
Bargiello et al. (2018)
8 more