› 5eti

X-ray diffraction
2.8Å resolution

Structure of dead kinase MAPK14

Released:
DOI: 10.2210/pdb5eti/pdb
PDB entry 5eti coloured by chain, front view.
PDB entry 5eti coloured by chain, side view.
PDB entry 5eti coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation.
Juyoux P, Galdadas I, Gobbo D, von Velsen J, Pelosse M, Tully M, Vadas O, Gervasio FL, Pellegrini E, Bowler MW
Science 381 1217-1225 (2023)
PMID: 37708276

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 42.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 45.418Å b: 87.023Å c: 122.921Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.175 0.225
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation.
Juyoux et al. (2023)
1 more

10 mentions without citation

HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells.
Planchais et al. (2019)
9 more