5eu3

X-ray diffraction
1.97Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137690 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
M-alpha Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 946 Da
Source organism: Homo sapiens
Expression system: synthetic construct
UniProt:
  • Canonical: P40967 (Residues: 280-288; Coverage: 1%)
Gene names: D12S53E, PMEL, PMEL17, SILV

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 52.81Å b: 80.37Å c: 56.06Å
α: 90° β: 112.79° γ: 90°
R-values:
R R work R free
0.2 0.197 0.255
Expression systems:
  • Escherichia coli
  • synthetic construct