› 5eu9

X-ray diffraction
2.05Å resolution

Structure of Human Enolase 2 in complex with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid

Released:
DOI: 10.2210/pdb5eu9/pdb
PDB entry 5eu9 coloured by chain, front view.
PDB entry 5eu9 coloured by chain, side view.
PDB entry 5eu9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Leonard PG, Muller FL

Function and Biology Details

Reaction catalysed: 
2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-enolase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 440 amino acids
Theoretical weight: 48.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P09104 (Residues: 1-434; Coverage: 100%)
Gene name: ENO2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 16 x MG
Ligand 5TX 8 x 5TX
Ligand PGE 6 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 119.251Å b: 110.31Å c: 136.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.154 0.192
Expression system: Escherichia coli BL21

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