› 5ew8

X-ray diffraction
1.63Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 35.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11362 (Residues: 458-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand 5SF 2 x 5SF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 209.11Å b: 57.89Å c: 65.26Å
α: 90° β: 107.51° γ: 90°
R-values:
R R work R free
0.186 0.185 0.206
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Achondroplasia: Development, pathogenesis, and therapy.
Ornitz et al. (2017)
14 more

13 mentions without citation

FGF19-FGFR4 Signaling in Hepatocellular Carcinoma.
Raja et al. (2019)
12 more