› 5exq

X-ray diffraction
1.6Å resolution

Human cytochrome c Y48H

Released:
DOI: 10.2210/pdb5exq/pdb
PDB entry 5exq coloured by chain, front view.
PDB entry 5exq coloured by chain, side view.
PDB entry 5exq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity.
Fellner M, Parakra R, McDonald KO, Kass I, Jameson GNL, Wilbanks SM, Ledgerwood EC
Biochem J 478 669-684 (2021)
PMID: 33480393

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome c Chains: A, B
Molecule details ›
Chains: A, B
Length: 104 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P99999 (Residues: 2-105; Coverage: 99%)
Gene names: CYC, CYCS
Sequence domains: Cytochrome c
Structure domains: Cytochrome c-like domain

Ligands and Environments

2 bound ligands:
Ligand HEC 2 x HEC
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 56.791Å b: 35.965Å c: 59.937Å
α: 90° β: 115.63° γ: 90°
R-values:
R R work R free
0.174 0.173 0.193
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

Effect on intrinsic peroxidase activity of substituting coevolved residues from Ω-loop C of human cytochrome c into yeast iso-1-cytochrome c.
Frederick et al. (2022)
2 more